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1

Anticoagulant peptides from Ancylostoma caninum are immunologically distinct and localize to separate structures within the adult hookworm

Juliusz Mieszczanek, Lisa M. Harrison, George P. Vlasuk, Michael Cappello

Journal:

Molecular and Biochemical Parasitology

Year:

2004

Language:

english

File:

PDF, 123 KB

english, 2004

2

Selective Inhibition of the Prothrombinase Complex: Factor Va Alters Macromolecular Recognition of a Tick Anticoagulant Peptide Mutant by Factor Xa †,‡

Betz, Andreas, Vlasuk, George P., Bergum, Peter W., Krishnaswamy, Sriram

Journal:

Year:

1997

Language:

english

File:

PDF, 209 KB

english, 1997

3

Liver endoplasmic reticulum polypeptides resolved by two-dimensional gel electrophoresis

George P. Vlasuk, Frederick G. Walz Jr.

Journal:

Analytical Biochemistry

Year:

1980

Language:

english

File:

PDF, 2.69 MB

english, 1980

4

Crystallographic structure of a peptidyl keto acid inhibitor and human α-thrombin

Kjell Håkansson, A. Tulinsky, Matthew M. Abelman, Todd A. Miller, George P. Vlasuk, Peter W. Bergum, Marguerita S.L. Lim-Wilby, Terence K. Brunck

Journal:

Bioorganic & Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 828 KB

english, 1995

5

Optimization of temperature–glycerol–pH conditions for a fed-batch fermentation process for recombinant hookworm (Ancylostoma caninum) anticoagulant peptide (AcAP-5) production by Pichia pastoris

Mehmet Inan, Vijay Chiruvolu, Kent M. Eskridge, George P. Vlasuk, Kenneth Dickerson, Scott Brown, Michael M. Meagher

Journal:

Enzyme and Microbial Technology

Year:

1999

Language:

english

File:

PDF, 216 KB

english, 1999

6

Recombinant nematode anticoagulant protein c2 and other inhibitors targeting blood coagulation factor VIIa/tissue factor

A. Y. Y. Lee, G. P. Vlasuk

Journal:

Journal of Internal Medicine

Year:

2003

Language:

english

File:

PDF, 176 KB

english, 2003

7

NMR structure determination of tick anticoagulant peptide (TAP)

Marguerita S.L. Lim-Wilby, George P. Vlasuk, Terence K. Brunck, Klaas Hallenga, Marc De Maeyer, Ignace Lasters

Journal:

Protein Science

Year:

1995

Language:

english

File:

PDF, 4.32 MB

english, 1995

8

Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an α-keto-amide transition-state mimetic

Raman Krishnan, A. Tulinsky, George P. Vlasuk, Daniel Pearson, Pureza Vallar, Peter Bergum, Terence K. Brunck, William C. Ripka

Journal:

Protein Science

Year:

1996

Language:

english

File:

PDF, 7.09 MB

english, 1996

9

Endotoxaemia induces resistance to activated protein C in healthy humans

Anne-Cornélie J. M. De Pont, Kamran Bakhtiari, Barbara A. Hutten, Evert De Jonge, George P. Vlasuk, William E. Rote, Marcel Levi, Harry R. Büller, Joost C. M. Meijers

Journal:

British Journal of Haematology

Year:

2006

Language:

english

File:

PDF, 199 KB

english, 2006

10

Recombinant nematode anticoagulant protein c2, an inhibitor of tissue factor/factor VIIa, attenuates coagulation and the interleukin-10 response in human endotoxemia

A. C. J. M. De Pont, A. H. M. Moons, E. De Jonge, J. C. M. Meijers, G. P. Vlasuk, W. E. Rote, H. R. Büller, T. Van Der Poll, M. Levi

Journal:

Journal of Thrombosis and Haemostasis

Year:

2004

Language:

english

File:

PDF, 147 KB

english, 2004

11

Effect of tiplaxtinin (PAI-039), an orally bioavailable PAI-1 antagonist, in a rat model of thrombosis

J. K. HENNAN, G. A. MORGAN, R. E. SWILLO, T. M. ANTRILLI, C. MUGFORD, G. P. VLASUK, S. J. GARDELL, D. L. CRANDALL

Journal:

Journal of Thrombosis and Haemostasis

Year:

2008

Language:

english

File:

PDF, 288 KB

english, 2008

12

10.1038/36862

Collen, Désiré, Rosen, Elliot D., Chan, Joyce C. Y., Idusogie, Esohe, Clotman, Frédéric, Vlasuk, George, Luther, Thomas, Jalbert, Louise R., Albrecht, Sybille, Zhong, Liang, Lissens, Ann, Schoonjans,

Journal:

Year:

1997

Language:

english

File:

PDF, 563 KB

english, 1997

13

10.1038/368666a0

Collen, Désiré, Rosen, Elliot D., Chan, Joyce C. Y., Idusogie, Esohe, Clotman, Frédéric, Vlasuk, George, Luther, Thomas, Jalbert, Louise R., Albrecht, Sybille, Zhong, Liang, Lissens, Ann, Schoonjans,

Journal:

Year:

1994

File:

PDF, 146 KB

1994

14

Surface Expression and Ligand-Based Selection of cDNAs Fused to Filamentous Phage Gene VI

Jespers, Laurent S., Messens, Joris H., Keyser, Annick De, Eeckhout, Dominique, Brande, Ilse Van Den, Gansemans, Yannick G., Lauwereys, Marc J., Vlasuk, George P., Stanssens, Patrick E.

Journal:

Year:

1995

File:

PDF, 962 KB

1995

15

Characterisation of a novel Kunitz-type molecule from the trematode Fasciola hepatica

S.Esther Bozas, Michael Panaccio, Jenette Creaney, Marina Dosen, James C. Parsons, George V. Vlasuk, Ian D. Walker, Terry W. Spithill

Journal:

Molecular and Biochemical Parasitology

Year:

1995

Language:

english

File:

PDF, 1.09 MB

english, 1995

16

Effect of inhibitors of factor Xa or platelet adhesion, heparin, and aspirin on platelet deposition in an atherosclerotic rabbit model of angioplasty injury

Elizabeth Marsh Lyle, Tsuneo Fujita, Michael W. Conner, Thomas M. Connolly, George P. Vlasuk, Joseph L. Lynch Jr

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

1995

Language:

english

File:

PDF, 1.08 MB

english, 1995

17

Inhibition of Factor VIIa/Tissue Factor with Nematode Anticoagulant Protein c2: From Unique Mechanism to a Promising New Clinical Anticoagulant

George P Vlasuk, William E Rote

Journal:

Trends in Cardiovascular Medicine

Year:

2002

Language:

english

File:

PDF, 2.64 MB

english, 2002

18

Liver microsomal polypeptides from Fischer-344 rats affected by age, sex, and xenobiotic induction

George P. Vlasuk, Frederick G. Walz Jr.

Journal:

Archives of Biochemistry and Biophysics

Year:

1982

Language:

english

File:

PDF, 3.75 MB

english, 1982

19

The hydrolysis and resynthesis of a single reactive site peptide bond in recombinant antistasin by coagulation factor Xa

Christopher T. Dunwiddie, George P. Vlasuk, Elka M. Nutt

Journal:

Archives of Biochemistry and Biophysics

Year:

1992

Language:

english

File:

PDF, 1.14 MB

english, 1992

20

Structure and analysis of the bovine atrial natriuretic peptide precursor gene

George P. Vlasuk, Judith Miller, Gerard H. Bencen, John A. Lewicki

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 430 KB

english, 1986

21

Synthetic tumor-derived human hypercalcemic factor exhibits parathyroid hormone-like vasorelaxation in renal arteries

Raymond J. Winquist, Elizabeth P. Baskin, George P. Vlasuk

Journal:

Biochemical and Biophysical Research Communications

Year:

1987

Language:

english

File:

PDF, 372 KB

english, 1987

22

Ca2+ efflux from liver mitochondria induced by a decrease in extramitochondrial pH

J. Tsokos, T.F. Cornwell, G. Vlasuk

Journal:

Year:

1980

Language:

english

File:

PDF, 338 KB

english, 1980

23

Functional multiplicity of atrial natriuretic peptide receptors on cultured rat Leydig tumor cells

George P. Vlasuk, Karen E. Arcuri, Terry M. Ciccarone, Ruth F. Nutt

Journal:

Year:

1988

Language:

english

File:

PDF, 421 KB

english, 1988

24

Cardiovascular and metabolic disease: new opportunities for therapy

George P Vlasuk, Robert M Scarborough

Journal:

Current Opinion in Pharmacology

Year:

2005

Language:

english

File:

PDF, 68 KB

english, 2005

25

Role of the V1 vasopressin receptor in pressure overload-induced cardiac hypertrophy

David L. Crandall, Viera Kasparcova, Hillary M. Semus, George P. Vlasuk, Orlando P. Bueno

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2007

Language:

english

File:

PDF, 50 KB

english, 2007

26

Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys

Thomas W Geisbert, Lisa E Hensley, Peter B Jahrling, Tom Larsen, Joan B Geisbert, Jason Paragas, Howard A Young, Terry M Fredeking, William E Rote, George P Vlasuk

Journal:

Year:

2003

Language:

english

File:

PDF, 958 KB

english, 2003

27

Tick anticoagulant peptide: kinetic analysis of the recombinant inhibitor with blood coagulation factor X.alpha.

Jordan, Susan P., Waxman, Lloyd, Smith, Donna E., Vlasuk, George P.

Journal:

Year:

1990

Language:

english

File:

PDF, 719 KB

english, 1990

28

APJ acts as a dual receptor in cardiac hypertrophy

Scimia, Maria Cecilia, Hurtado, Cecilia, Ray, Saugata, Metzler, Scott, Wei, Ke, Wang, Jianming, Woods, Chris E., Purcell, Nicole H., Catalucci, Daniele, Akasaka, Takeshi, Bueno, Orlando F., Vlasuk, Ge

Journal:

Year:

2012

Language:

english

File:

PDF, 802 KB

english, 2012

29

Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa

Waxman, L, Smith, D., Arcuri, K., Vlasuk, G.

Journal:

Year:

1990

Language:

english

File:

PDF, 1.19 MB

english, 1990

30

Anticoagulant effects of the selective factor Xa inhibitors tick anticoagulant peptide and antistasin in the APTT assay are determined by the relative rate of prothrombinase inhibition

Christopher T. Dunwiddie, Donna E. Smith, Elka M. Nutt, George P. Vlasuk

Journal:

Thrombosis Research

Year:

1991

Language:

english

File:

PDF, 606 KB

english, 1991

31

Enhancement of recombinant tissue plasminogen activator-induced reperfusion by recombinant tick anticoagulant peptide, a selective factor Xa inhibitor, in a canine model of femoral arterial thrombosis

M.J. Mellott, M.T. Stranieri, G.R. Sitko, I.I. Stabilito, J.J. Lynch Jr., G.P. Vlasuk

Journal:

Fibrinolysis and Proteolysis

Year:

1993

Language:

english

File:

PDF, 921 KB

english, 1993

32

Proalbumin is bound to the membrane of rat liver smooth microsomes

George P. Vlasuk, B. John Ghraye, Frederick G. Walz Jr.

Journal:

Biochemical and Biophysical Research Communications

Year:

1980

Language:

english

File:

PDF, 1.09 MB

english, 1980

33

A blinded multicenter dose escalation phase IIa study of the factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in patients undergoing elective percutaneous coronary intervention

Amo H. Moons, N.R. Bijsterveld, H.R. Büller, M.H. Prins, W.E. Rote, G.P. Vlasuk, R.J. Peters

Journal:

Journal of the American College of Cardiology

Year:

2002

Language:

english

File:

PDF, 174 KB

english, 2002

34

Recombinant nematode anticoagulant protein c2, an inhibitor of the tissue factor/factor VIIa complex, in patients undergoing elective coronary angioplasty

Arno H.M Moons, Ron J.G Peters, Nick R Bijsterveld, Jan J Piek, Martin H Prins, George P Vlasuk, William E Rote, Harry R Büller

Journal:

Journal of the American College of Cardiology

Year:

2003

Language:

english

File:

PDF, 128 KB

english, 2003

35

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

Mitchell, Sarah J., Martin-Montalvo, Alejandro, Mercken, Evi M., Palacios, Hector H., Ward, Theresa M., Abulwerdi, Gelareh, Minor, Robin K., Vlasuk, George P., Ellis, James L., Sinclair, David A., Daw

Journal:

Year:

2014

Language:

english

File:

PDF, 1.05 MB

english, 2014

36

A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes

Baksi, Arun, Kraydashenko, Oleg, Zalevkaya, Alsu, Stets, Roman, Elliott, Peter, Haddad, Jonathan, Hoffmann, Ethan, Vlasuk, George P., Jacobson, Eric W.

Journal:

British Journal of Clinical Pharmacology

Year:

2014

Language:

english

File:

PDF, 677 KB

english, 2014

37

Identification of Atrial Natriuretic Factor Gene Transcripts in the Central Nervous System of the Rat

D. G. Gardner, G. P. Vlasuk, J. D. Baxter, J. C. Fiddes and J. A. Lewicki

Journal:

Proceedings of the National Academy of Sciences

Year:

1987

Language:

english

File:

PDF, 1023 KB

english, 1987

38

Antimalarial Activities of Novel Synthetic Cysteine Protease Inhibitors

Lee, B. J., Singh, A., Chiang, P., Kemp, S. J., Goldman, E. A., Weinhouse, M. I., Vlasuk, G. P., Rosenthal, P. J.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2003

Language:

english

File:

PDF, 167 KB

english, 2003

39

Multiplicity, strain differences, and topology of phenobarbital-induced cytochromes P-450 in rat liver microsomes

Vlasuk, George P., Ghrayeb, John, Ryan, Dene E., Reik, Linda, Thomas, Paul E., Levin, Wayne, Walz, Frederick G.

Journal:

Year:

1982

Language:

english

File:

PDF, 6.99 MB

english, 1982

40

Polypeptide patterns of hepatic microsomes from Long-Evans rats treated with different xenobiotics

Vlasuk, George P., Ryan, Dene E., Thomas, Paul E., Levin, Wayne, Walz, Frederick G.

Journal:

Year:

1982

Language:

english

File:

PDF, 2.57 MB

english, 1982

41

Assembly of the Prothrombinase Complex Enhances the Inhibition of Bovine Factor Xa by Tick Anticoagulant Peptide

Krishnaswamy, Sriram, Vlasuk, George P., Bergum, Peter W.

Journal:

Year:

1994

Language:

english

File:

PDF, 1.47 MB

english, 1994

42

Species differences in cytochromes P-450 and epoxide hydrolase: comparisons of xenobiotic-induced hepatic microsomal polypeptides in hamsters and rats

Walz, Frederick G., Vlasuk, George P., Steggles, Alan W.

Journal:

Year:

1983

Language:

english

File:

PDF, 5.61 MB

english, 1983

43

Site-directed analysis of the functional domains in the factor Xa inhibitor tick anticoagulant peptide: identification of two distinct regions that constitute the enzyme recognition sites

Dunwiddie, Christopher T., Neeper, Michael P., Nutt, Elka M., Waxman, Lloyd, Smith, Donna E., Hofmann, Kathryn J., Lumma, Patricia K., Garsky, Victor M., Vlasuk, George P.

Journal:

Year:

1992

Language:

english

File:

PDF, 770 KB

english, 1992

44

Site-directed analysis of the functional domains in the factor Xa inhibitor tick anticoagulant peptide: identification of two distinct regions that constitute the enzyme recognition sites. [Erratum to document cited in CA117(25):247598n]

Dunwiddie, Christopher T., Neeper, Michael P., Nutt, Elka M., Waxman, Lloyd, Smith, Donna E., Hofmann, Kathryn J., Lumma, Patricia K., Garsky, Victor M., Vlasuk, George P.

Journal:

Year:

1993

Language:

english

File:

PDF, 36 KB

english, 1993

45

SIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR

Dai, H., Kustigian, L., Carney, D., Case, A., Considine, T., Hubbard, B. P., Perni, R. B., Riera, T. V., Szczepankiewicz, B., Vlasuk, G. P., Stein, R. L.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 1.70 MB

english, 2010

46

The actions of atrial natriuretic factor on the vascular wall

Vlasuk, George P., Babilon, Robert W., Nutt, Ruth F., Ciccarone, Terry M., Winquist, Raymond J.

Journal:

Canadian Journal of Physiology and Pharmacology

Year:

1987

Language:

english

File:

PDF, 706 KB

english, 1987

47

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism

Hubbard, Basil P, Loh, Christine, Gomes, Ana P, Li, Jun, Lu, Quinn, Doyle, Taylor LG, Disch, Jeremy S, Armour, Sean M, Ellis, James L, Vlasuk, George P, Sinclair, David A

Journal:

Year:

2013

Language:

english

File:

PDF, 1.62 MB

english, 2013

48

Nematode Anticoagulant Protein c2 Reveals a Site on Factor Xa That Is Important for Macromolecular Substrate Binding to Human Prothrombinase

Buddai, S. K., Toulokhonova, L., Bergum, P. W., Vlasuk, G. P., Krishnaswamy, S.

Journal:

Journal of Biological Chemistry

Year:

2002

Language:

english

File:

PDF, 774 KB

english, 2002

49

Ability of Recombinant Factor VIIa to Generate Thrombin During Inhibition of Tissue Factor in Human Subjects

Friederich, P. W., Levi, M., Bauer, K. A., Vlasuk, G. P., Rote, W. E., Breederveld, D., Keller, T., Spataro, M., Barzegar, S., Buller, H. R.

Journal:

Year:

2001

Language:

english

File:

PDF, 404 KB

english, 2001

50

Conjunctive enhancement of enzymatic thrombolysis and prevention of thrombotic reocclusion with the selective factor Xa inhibitor, tick anticoagulant peptide. Comparison to hirudin and heparin in a canine model of acute coronary artery thrombosis

Sitko, G. R., Ramjit, D. R., Stabilito, I. I., Lehman, D., Lynch, J. J., Vlasuk, G. P.

Journal:

Year:

1992

Language:

english

File:

PDF, 2.35 MB

english, 1992

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